Eoin's research interests are focussed on the expression, function and degradation of ER associated proteins, in particular, the histidine decarboxylase (HDC) enzyme that catalyzes the formation of histamine, and HFE, which is involved in regulating cellular iron metabolism. Treatment of histamine related diseases can conservatively be estimated to cost Irish patients many millions of euros every year, while the most common inherited disease in Ireland, hereditary haemochromatosis, is associated with mutations in the HFE gene. Eoin is particularly interested in characterizing the manner in which these two proteins are degraded with the aim of providing new insights into how they are regulated physiologically, or how they could potentially be regulated pharmacologically.